Browse the latest research summaries in the field of biomedical for spinal cord injury patients and caregivers.
Showing 801-810 of 850 results
TISSUE ENGINEERING: Part A, 2021 • May 28, 2021
This study investigates the spatial relationships between regenerating axons and blood vessels within hydrogel scaffolds implanted into spinal cord injuries in rats. The findings revealed that Schwann...
KEY FINDING: Scaffolds containing Schwann cells (SCs) significantly enhanced axonal regeneration and blood vessel formation compared to Matrigel-only (MG) or SCs with rapamycin (RAPA).
Scientific Reports, 2023 • October 20, 2023
This study successfully synthesized GO using a modified Hummer's method and immobilized cABC I on it, characterized using XRD, FTIR, and SEM. The immobilized cABC I on GO followed Michaelis-Menten kin...
KEY FINDING: Immobilization of cABC I on GO resulted in a greater Km and lower Vmax compared to the free enzyme.
Journal of Biomedical Optics, 2011 • October 4, 2011
This study investigates myelin integrity in mice with relapsing experimental autoimmune encephalomyelitis (EAE) using coherent anti-Stokes Raman scattering (CARS) microscopy. The research demonstrates...
KEY FINDING: Paranodal myelin retraction is an early event in relapsing experimental autoimmune encephalomyelitis (EAE), occurring at the onset of the disease and at the borders of acute demyelinating lesions.
Biomaterials, 2009 • April 1, 2009
This study investigates surface immobilization to deliver complexed DNA (lipoplexes) from a multiple channel bridge in order to promote transgene expression in the injured spinal cord using low quanti...
KEY FINDING: Fibronectin, an ECM protein, produced greater gene expression levels and immobilization efficiencies compared with collagen and laminin.
Journal of NeuroEngineering and Rehabilitation, 2017 • June 28, 2017
This study evaluated the long-term performance of spiral nerve cuff electrodes implanted in 14 human volunteers for motor or sensory neuroprostheses. The results indicated that the majority of the imp...
KEY FINDING: The spiral nerve cuffs examined remain functional in motor and sensory neuroprostheses for 2–11 years after implantation.
Frontiers in Cell and Developmental Biology, 2022 • November 24, 2022
This study developed an icariin-loaded chitosan hydrogel (ICA/CTS) for cartilage regeneration, leveraging icariin's chondrogenic and anti-inflammatory properties. In vitro results demonstrated sustain...
KEY FINDING: The ICA/CTS hydrogel exhibited a favorable in vitro anti-inflammatory effect, suppressing inflammatory-related cytokines.
Bioactive Materials, 2021 • May 8, 2021
This study developed an injectable and self-healing hydrogel composed of Fmoc-grafted chitosan (FC) and Fmoc peptide (FI) for spinal cord injury (SCI) repair. The hydrogel's unique π-π stacking intera...
KEY FINDING: The FC/FI hybrid hydrogel exhibited excellent injectable and self-healing properties due to the dynamic reversible π-π stacking interactions of the fluorenyl rings.
Frontiers in Bioengineering and Biotechnology, 2022 • June 21, 2022
This review discusses the characteristics of hydrogels and their advantages as delivery vehicles for SCI repair, covering hydrogel therapy alone or combined with cells and molecules. Hydrogels can eff...
KEY FINDING: Hydrogels can serve as structural scaffolds for tissues, promoting cell proliferation, migration, and differentiation, thereby accelerating the repair of damaged tissue in SCI.
Bioactive Materials, 2021 • April 13, 2021
This review focuses on anisotropic topography and scaffolds for regenerating long-gap PNI (>10 mm) and SCI, covering anatomies of native nerves/cords and requirements for regenerative scaffold designs...
KEY FINDING: Anisotropic structures resembling the native extracellular matrix (ECM) can effectively guide neural outgrowth and reconnection.
Analytical and Bioanalytical Chemistry, 2018 • April 18, 2018
Neural progenitor cells were cultured on electrospun P(HB-co-HHx) fiber substrates coated with either laminin or poly-L-lysine/laminin. At different times after cell seeding, the samples were fixed an...
KEY FINDING: Changes in lipid and amide I–II spectral regions are modulated by the type and coating of the substrate used and the culture time.